![]() ![]() Studies on CPA meningiomas with IAC involvement have focused, for example, on functional preservation during surgery, the effects of radiotherapy, angiographic findings, and skull-base bone involvement. Despite advances in neurosurgery, the surgical procedure for CPA meningiomas involving the IAC remains challenging. Nonetheless, the anatomical location and intimate relationship between meningiomas involving the IAC and the cranial nerves are such that skilled surgical management is needed. Resection of these tumors is compatible with hearing restoration. Patients with CPA meningiomas with IAC involvement often present with hearing loss and abnormal facial motor function. The location of a CPA meningioma affects clinical outcome. While the first form is very rare, the second is relatively common. Meningiomal involvement of the IAC occurs in two forms: meningioma truly originating in the IAC and meningioma extending into the IAC from an adjacent location. Although enlargement and involvement of the internal auditory canal (IAC) is a common sign of schwannomas of the CPA, these features can also be seen in meningioma. Among intracranial meningiomas, 5%–10% are located in the cerebellopontine angle (CPA), thus comprising the second most common tumors in this anatomic region. Meningiomas account for 26% of primary intracranial neoplasms. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are creditedĭata Availability: All relevant data are within the paper.įunding: This research was supported by National Natural Science Foundation of China (81271541 to J.P. Received: SeptemAccepted: FebruPublished: April 7, 2015Ĭopyright: © 2015 Gao et al. PLoS ONE 10(4):Īcademic Editor: Karl Herholz, University of Manchester, UNITED KINGDOM Patients with intruding IAC were significantly older (54.5☙.54 years, P=0.021) and had the lowest postoperative residual tumor values (42%, χ 2=7.865, P= 0.005), while those with filled IAC were more likely to be female (95%, χ 2=9.404, P=0.009).Our observations provide the basis for a morphological classification of IAC involvement by CPA meningiomas and further insight into the clinical features of these tumors.Ĭitation: Gao K, Ma H, Cui Y, Chen X, Ma J, Dai J (2015) Meningiomas of the Cerebellopontine Angle: Radiological Differences in Tumors with Internal Auditory Canal Involvement and Their Influence on Surgical Outcome. Peritumoral edema was a risk factor for IAC involvement ( P=0.016, OR=2.186). The results showed that the 71 patients (36.8%) with IAC involvement had a higher ratio of peritumoral edema (χ 2=5.922, P=0.015), postoperative residual tumor (χ 2=22.183, P< 0.001), and a predominance of the meningothelial subtype (χ 2=5.89, P=0. Patient age, sex, tumor volume, postoperative residual tumor, and pathological subtype were compared in patients with and without IAC involvement by the tumor and among the different types of IAC involvement. The pre- and postoperative MR images of 193 consecutive patients with pathologically diagnosed meningioma centered around the IAC were analyzed, focusing on changes in the IAC, maximal axial tumor volume, peritumoral brain edema, and postoperative residual tumor. This study explored the clinical, radiological, and pathological characteristics of cerebellopontine angle (CPA) meningiomas with internal auditory canal (IAC) involvement. ![]()
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